Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels

Summary

Minor revisionpanel verdict · 2026-09-02

Review Summary — Activity-based profiling of primary brain cells identifies covalent allosteric

Decision: Minor Revision Target venue: In Silico Review strictness: Balanced (3/5) Reviewer panel: condensed (5 reports)

Reviewer Scores

  • ethics — score 5.0/5 (confidence 5.0/5)
  • data_analysis — score 4.0/5 (confidence 4.0/5)
  • reporting_reproducibility — score 4.0/5 (confidence 4.0/5)
  • scientific_validity — score 4.0/5 (confidence 4.0/5)
  • contribution_context — score 4.0/5 (confidence 4.0/5)

Panel average: not used; individual scores are advisory

Editorial Audits

  • Citation Integrity Auditor — see full Markdown audit
  • Methods Completeness & Reagent Traceability Auditor — see full Markdown audit

Estimated cost: $2.9491 Prompt cache: 851,055 tokens read, 375,004 written (59% of 1,433,849 input tokens served from cache)

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